What Is MOTS-c?
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial genome. First identified in 2015, this peptide has rapidly gained attention in metabolic research for its unique mechanism of action and potential role in cellular energy regulation.
Mechanism of Action
Current research indicates MOTS-c exerts its effects primarily through:
- AMPK activation — Directly activates AMP-activated protein kinase.
- Glucose uptake enhancement — Promotes GLUT4 transporter translocation.
- Fatty acid oxidation — Shifts metabolism toward fat oxidation.
- Insulin sensitivity modulation — Improves cellular response to insulin signaling.
Research Applications
- Metabolic syndrome and insulin resistance models
- Aging-related metabolic decline
- Exercise mimetics research
- Obesity and adipose tissue regulation
- Cardiovascular protection in ischemic models
CoreVionRX supplies research-grade MOTS-c (40mg lyophilized) with 99%+ HPLC-verified purity. Full COA and batch traceability included.
